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Background Information:
EPZ005687 is a potent and selective small molecule inhibitor of histone methyltransferase EZH2 ( Ki = 24 nM). It has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme EZH1.
Reference:
1. SK Knutson, et al., A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells, Nat Chem Biol. 2012 Nov;8(11):890-6.
APIM050325: EPZ005687
CAS No.: 1396772-26-1.
Molecular Formula: C32H37N5O3 ? 0.8HCl.
Molecular Weight: 568.8.
Purity: >99.5% (HPLC at 214 and 254 nm),
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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