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Background Information:
GS-4997 (Selonsertib), a clinical stage, orally bioavailable small molecule, is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
APIM050158: GS-4997 (SELONSERTIB)
CAS No.: 1448428-04-3.
Molecular Formula: C24H24FN7O.
Molecular Weight: 445.5 (or refer to Certificate of Analysis, batch-specific).
Purity: 99.5% by achiral HPLC, Lot 01.
QC: HPLC-MS, 1H-NMR and Quantitative Elemental Analysis.
Solubility: Refer to Certificate of Anlysis.
Storage: Refer to Certificate of Anlysis.
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