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Background Information:
LEE-011 is an orally bioavailable, potent and highly selective (most selective CDK4/6 inhibitor to date) cyclindependent kinase 4 and 6 (CDK 4/6) with IC50 at low nM, currently in clinical trials.
Reference:
1. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Oct 28.
APIM050180: LEE011 (RIBOCICLIB)
CAS No.: 1211441-98-3.
Molecular Formula: C23H30N8O.
Molecular Weight: 434.5 (or refer to Certificate of Analysis, batch-specific).
Purity: >99.5% (HPLC, detected at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, and water with 2.0 eq. of HCl.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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