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Background Information:
A potent, selective and orally bioavailable mTOR inhibitor currently in clinical trial.
Reference:
1. N. Cayarol, et al., Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells, PNAS, 2010 107 (28) 12469-12474.* Confirmed by a quantitative elemental analysis.
APIM050213: OSI-027
CAS No.: 936890-98-1.
Molecular Formula: C21H22N6O3 ?1.3CF3CO2H.
Molecular Weight: 554.1.
Purity: 99% (HPLC at 220 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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