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Background Information:
A cytotoxic antimicrotubule agent. It binds to tubulin and inhibits the disassembly of microtubules, thereby inhibiting cell division. It also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2).
Reference:
1. Georgiadis MS, Russell EK, Gazdar AF, Johnson BE., Paclitaxel cytotoxicity against human lung cancer cell lines increases with prolonged exposure durations, Clin Cancer Res. 1997 Mar;3(3):449-54.
2. Wang J, Lou P, Lesniewski R, Henkin J., Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly, Anticancer Drugs. 2003 Jan;14(1):13-9.
APIM050307: PACLITAXEL
CAS No.: 33069-62-4.
Molecular Formula: C47H51NO14.
Molecular Weight: 853.91.
Purity: >99.5% (by HPLC).
QC: HPLC, H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Soluble in alcohols, and common organic solvents.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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